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Analgesic and other effects of the d ‐ and l ‐isomers of pentazocine
Author(s) -
Forrest William H.,
Beer E. George,
Bellville J. Weldon,
Ciliberti Benjamin J.,
Miller Elliott V.,
Paddock Richard
Publication year - 1969
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1969104468
Subject(s) - pentazocine , morphine , analgesic , sedation , potency , anesthesia , pharmacology , chemistry , medicine , biochemistry , in vitro
The d‐ and l‐isomers of pentazocine were compared with morphine for analgesia and other effects in two randomized, double‐blind assays involving 889 treatments in 478 patients, given principally for postoperative pain. Response to 60 mg. of d‐pentazocine was less than that to 5 mg. of morphine. Relative potency for l‐pentazocine based on effects measured up to 255 minutes was found to be 0.35 to 0.40 (25 to 29 mg. ~ 10 mg. of morphine). Sedation and sweating were common with the l‐isomer. It appears that analgesia resides principally in the l‐isomer