Premium
Scopolamine on heart rates in man
Author(s) -
Gravenstein J. S.,
Thornby J. I.
Publication year - 1969
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1969103395
Subject(s) - atropine , scopolamine , bradycardia , heart rate , tachycardia , parasympatholytic , anesthesia , medicine , blood pressure , muscarinic acetylcholine receptor , receptor
In normal volunteers scopolamine, 0.025 to 0.2 mg. per 70 Kg., injected rapidly intravenously, decreased heart rate within 10 minutes by about 12 to 15 beats per minute. Doses ranging from 0.3 to 0.6 mg. first increased and then decreased heart rates. The data suggest that the rate changes after intravenous dases of 0.3 mg. per 70 Kg. or more of scopolamine were the result of a bradycardia‐producing component and a tachycardia‐producing component. Atropine, 0.2 mg. per 70 Kg., injected intravenously 180 minutes after the scopolamine, failed to affect rate significantly when it had been preceded by one of the lower doses of scopolamine but increased rate when one of the higher doses of scopolamine had been injected previously.