Premium
Analgesic and side effects of pentazocine and morphine in a large population of postoperative patients
Author(s) -
Paddock Richard,
Beer E. George,
Bellville J. Weldon,
Ciliberti Benjamin J.,
Forrest William H.,
Miller Elliott V.
Publication year - 1969
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1969103355
Subject(s) - pentazocine , morphine , analgesic , potency , medicine , anesthesia , chemistry , biochemistry , in vitro
The analgesic and side effects of pentazocine were compared with those of morphine in 1,074 surgical patients. Three separate three‐point assays were conducted. Standard doses used were 5 mg. and 10 mg. of morphine and 10 mg., 20 mg., and 40 mg. of pentazocine. The relative analgesic potency, based on a 225 minute time period for analgesic effect, was 0.28 (36 mg. of pentazocine ≃ 10 mg. of morphine). For peak pain intensity difference, the relative potency was found to be 0.38 (27 mg. of pentazocine ≃ 10 mg. of morphine).