Analgesic and side effects of pentazocine and morphine in a large population of postoperative patients | Zendy

Paddock Richard | Zendy; Beer E. George | Zendy; Bellville J. Weldon | Zendy; Ciliberti Benjamin J. | Zendy; Forrest William H. | Zendy; Miller Elliott V. | Zendy

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Analgesic and side effects of pentazocine and morphine in a large population of postoperative patients

Author(s) -

Paddock Richard,

Beer E. George,

Bellville J. Weldon,

Ciliberti Benjamin J.,

Forrest William H.,

Miller Elliott V.

Publication year - 1969

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1002/cpt1969103355

Subject(s) - pentazocine , morphine , analgesic , potency , medicine , anesthesia , chemistry , biochemistry , in vitro

The analgesic and side effects of pentazocine were compared with those of morphine in 1,074 surgical patients. Three separate three‐point assays were conducted. Standard doses used were 5 mg. and 10 mg. of morphine and 10 mg., 20 mg., and 40 mg. of pentazocine. The relative analgesic potency, based on a 225 minute time period for analgesic effect, was 0.28 (36 mg. of pentazocine ≃ 10 mg. of morphine). For peak pain intensity difference, the relative potency was found to be 0.38 (27 mg. of pentazocine ≃ 10 mg. of morphine).

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