Chlorpromazine‐procyclidine and imipramine: Effects on thyroid function in psychiatric patients | Zendy

Blumberg Arnold G. | Zendy; Klein Donald F. | Zendy

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Chlorpromazine‐procyclidine and imipramine: Effects on thyroid function in psychiatric patients

Author(s) -

Blumberg Arnold G.,

Klein Donald F.

Publication year - 1969

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1002/cpt1969103350

Subject(s) - chlorpromazine , imipramine , placebo , medicine , thyroid function , pharmacology , thyroid , endocrinology , pathology , alternative medicine

A series of thyroid function tests were performed on 84 randomly assigned psychiatric patients receiving chlorpromazine‐procyclidine, imipramine, or placebo, before and after treatment. The rate of uptake of 1s1 I and the 24 hour level of uptake of 1s1 I by the thyroid gland was increased by chlorpromazine‐procyclidine but not by imipramine. Renal clearance of 1s1 I was diminished by treatment with chlorpromazine‐procyclidine but not by imipramine. PBI, T 3 resin uptake, and ankle jerk were not significantly altered.

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