Premium
Comparative evaluation of Rauwolfia whole root and reserpine
Author(s) -
Smith W. M.,
Thurm R. H.,
Bromer L.
Publication year - 1969
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1969103338
Subject(s) - chlorothiazide , reserpine , placebo , medicine , pharmacology , diuretic , alternative medicine , pathology
To compare the antihypertensive effect of a Rauwolfia whole root‐chlorothiazide combination with reserpine plus chlorothiazide, subjects were selected who had average diastolic pressures of 90 mm. Hg or more at home, in the sitting position. In a double‐blind study providing 3 months on each regimen with a 6 week placebo period intervening, no significant difference in antihypertensive effect was demonstrated between the whole root Rauwolfia‐chlorothiazide combination and the reserpine plus chlorothiazide.