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Relationship of pentazocine plasma levels to pharmacological activity in man
Author(s) -
Berkowitz Barry A.,
Asling Joseph H.,
Shnider Sol M.,
Way E. Leong
Publication year - 1969
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1969103320
Subject(s) - pentazocine , liter , plasma levels , plasma concentration , anesthesia , intramuscular injection , medicine , chemistry , pharmacology , analgesic
A spectrophotofluorometric method for the quantitative determination of pentazocine plasma levels in man, which detects concentrations as low as 0.03 µg per milliliter is described. Following intramuscular and oral administration, plasma levels of pentazocine coincide closely with onset, duration, and intensity of analgesia, as well as with other pharmacologic effects. The mean peak plasma level after 45 mg. per 70 Kg., intramuscularly, was 0.14 p,g per milliliter. The mean peak plasma level after 75 mg. orally was 0.16 µg per milliliter, but as much as 25 per cent are biotransformation products. The plasma half‐life is about 2 hours after intravenous or intramuscular administration. Side effects of pentazocine may be more prominent in ambulatory subjects or in those experiencing minimal pain.