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A comparison of the behavioral effects of periodic administration of chlorpromazine and a “sustained‐release” form of chlorpromazine
Author(s) -
Orzack Maressa Hecht,
Taylor Constance L.,
Kornetsky Conan
Publication year - 1969
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1969102258
Subject(s) - chlorpromazine , anesthesia , crossover study , medicine , psychomotor learning , pharmacology , placebo , psychiatry , alternative medicine , cognition , pathology
The relative efficacy of 300 mg. of chlorpromazine in a “sustained‐release” form was compared with repeated doses of regular chlorpromazine in a double‐blind crossover study. Ten sub;ects, 5 normal volunteers and 5 chronic schizophrenic patients, were given 4 psychomotor tests. Two of these, the CPT and PDS, were primarily attention tests. Performance on all the tests but the DSST indicated differences between the 2 treatments. A decrement in performance of the CPT was found 4 hours after the sustained‐release treatment; it did not persist. Decrement in performance was not found in the regular chlorpromazine program, suggesting an initial “dumping” effect of the sustained‐release capsule. Performance on the SPDT and PDS tests demonstrated latent differences between drug treatments. There were increasing decrements in performance after repeated regular chlorpromazine, suggesting a cumulative effect. This was not found after the sustained‐release treatment. While the sustained‐release treatment is as effective during the midportion of the period of observation as the repeated administration of regular chlorpromazine, the effects start to wear off between 8 to 10 hours after the administration of the sustained‐release capsule; while, after repeated doses of regular chlorpromazine, there were increasing decrements in performance.