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A new approach to the use of histamine skin tests in the study of antihistamine drugs
Author(s) -
Joubert L.,
Gaut Z.,
Abrams W. B.
Publication year - 1969
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1969102250
Subject(s) - antihistamine , histamine , placebo , histamine antagonists , medicine , discriminator , pharmacology , skin test , histamine h1 receptor , histamine h1 antagonists , anesthesia , dermatology , computer science , alternative medicine , pathology , antagonist , receptor , telecommunications , tuberculosis , detector
Data are presented to show that the histamine skin test is more variable than previously appreciated. Dose‐response studies with the use of this test to evaluate antihistaminics should therefore include placebo and the use of the double‐blind technique. In this study the wheal alone appeared to be a sufficient discriminator of antihistamine activity.