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Cephaloglycin: Crossover absorption studies and clinical evaluation
Author(s) -
Perkins Robert L.,
Glontz Gary E.,
Saslaw Samuel
Publication year - 1969
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1969102244
Subject(s) - urinary system , urine , medicine , obstructive uropathy , crossover study , antibiotics , oral administration , absorption (acoustics) , cephaloridine , gastroenterology , urology , cephalosporin , chemistry , pathology , physics , alternative medicine , placebo , biochemistry , acoustics
Studies with volunteers on oral administration of cephaloglycin resulted in low serum but higher urinary concentrations. Although some absorption was observed with orally administered cephaloridine, serum levels were shorter in duration and urine concentrations were lower than those observed with cephaloglycin. Clinical evaluation indicated that cephaloglycin was effective in only 13 of 20 patients with acute lower respiratory infections, and the treatment failures observed in the present study suggest that it should not generally be used as a primary antibacterial agent for such infections. Despite the relatively high urinary concentrations observed after oral administration of cephaloglycin, 10 of 14 patients with chronic urinary tract infections exhibited treatment failures, possibly related in part to the presence of obstructive uropathy, urinary retention, or calculi.