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The influence of debrisoquin on the accumulation and metabolism of biogenic amines by the human platelet, in vivo and in vitro
Author(s) -
Solomon Harvey M.,
Ashley Constance,
Spirt Nena,
Abrams William B.
Publication year - 1969
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1969102229
Subject(s) - platelet , chemistry , in vivo , guanethidine , membrane , serotonin , pharmacology , in vitro , metabolism , biochemistry , monoamine neurotransmitter , hemostasis , biophysics , endocrinology , medicine , biology , receptor , microbiology and biotechnology , stimulation
Although the platelet has a specialized function in the control of hemostasis, 13 its membrane resembles that of many other cells. For example, the platelet maintains hydrogen ions against a concentration gradient 24 and actively transports certain amino acids and sugars. 23 , 25 In addition its membrane is permeable to several relatively large, lipid‐insoluble organic compounds. 23 The membrane of the platelet also shares certain characteristics with that of the adrenergic neuron; both cells actively accumulate such drugs as guanethidine 4 , 7 and debrisoquin. 5 , 9 In addition, desmethylimipramine inhibits the active uptake of serotonin by the platelet 20 and the active uptake of norepinephrine by the neuron. 1 , 12