The influence of debrisoquin on the accumulation and metabolism of biogenic amines by the human platelet, in vivo and in vitro | Zendy

Solomon Harvey M. | Zendy; Ashley Constance | Zendy; Spirt Nena | Zendy; Abrams William B. | Zendy

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The influence of debrisoquin on the accumulation and metabolism of biogenic amines by the human platelet, in vivo and in vitro

Author(s) -

Solomon Harvey M.,

Ashley Constance,

Spirt Nena,

Abrams William B.

Publication year - 1969

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1002/cpt1969102229

Subject(s) - platelet , chemistry , in vivo , guanethidine , membrane , serotonin , pharmacology , in vitro , metabolism , biochemistry , monoamine neurotransmitter , hemostasis , biophysics , endocrinology , medicine , biology , receptor , microbiology and biotechnology , stimulation

Although the platelet has a specialized function in the control of hemostasis, 13 its membrane resembles that of many other cells. For example, the platelet maintains hydrogen ions against a concentration gradient 24 and actively transports certain amino acids and sugars. 23 , 25 In addition its membrane is permeable to several relatively large, lipid‐insoluble organic compounds. 23 The membrane of the platelet also shares certain characteristics with that of the adrenergic neuron; both cells actively accumulate such drugs as guanethidine 4 , 7 and debrisoquin. 5 , 9 In addition, desmethylimipramine inhibits the active uptake of serotonin by the platelet 20 and the active uptake of norepinephrine by the neuron. 1 , 12

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