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Experimental production of pain in man: Sensitivity of a new method to 600 mg. of aspirin
Author(s) -
Smith Gene M.,
Beecher Henry K.
Publication year - 1969
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1969102213
Subject(s) - potency , aspirin , analgesic , medicine , anesthesia , tourniquet , pain relief , pharmacology , chemistry , in vitro , biochemistry
The acetylsalicylic acid equivalent of two standard commercial aspirin tablets significantly delays development of ischemic pain induced experimentally in man by the submaximum‐effort tourniquet technique. Results of the present study, in confunction with previous findings, indicate that a wide range of analgesic potency may be assessed with this method, and thus a long‐sought procedure for testing, in man, the potency of new analgesics, studied under controlled experimental conditions, is provided. Efforts are presently under way to refine and sensitize the method in order to increase its practical usefulness for study of analgesics with only modest potency.