Premium
Effect of drugs on ocular counterrolling
Author(s) -
Miller Earl F.,
Graybiel Ashton
Publication year - 1969
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196910192
Subject(s) - meprobamate , chlordiazepoxide , placebo , anesthesia , medicine , scopolamine , depressant , ingestion , amphetamine , diazepam , pharmacology , alternative medicine , pathology , dopamine
To determine the temporal effect of several drugs and placebo on ocular counterrolling, a specific indicator of otolith activity, measurements under controlled conditions were made before and at various times after oral administration. Nine normal subjects participated, and from 4 to 6 subjects participated in each experimental trial. Alcohol, 1 c.c. per pound of body weight, had a marked and progressive depressant effect on the amount of eye roll during the intoxication period; complete recovery was recorded 6 hours after its ingestion. Scopolamine, meclizine, acetylsalicylic acid, meprobamate, chlordiazepoxide hydrochloride, d‐amphetamine, and diphenidol, given in twice the usually recommended doses, had little or no effect.