Premium
The effects of phenobarbital, chloral betaine, and glutethimide administration on warfarin plasma levels and hypoprothrombinemic responses in man
Author(s) -
MacDonald Murdo G.,
Robinson Donald S.,
Sylwester David,
Jaffe Julian J.
Publication year - 1969
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196910180
Subject(s) - glutethimide , phenobarbital , warfarin , chloral hydrate , placebo , chemistry , pharmacology , chloral , hypnotic , anesthesia , medicine , alternative medicine , pathology , atrial fibrillation , organic chemistry
Ten male volunteers received phenobarbital, glutethimide, chloral betaine, and a placebo at bedtime for 3 week periods. Plasma warfarin levels and prothrombin times were determined after a single oral dose of warfarin prior to and immediately following placebo or hypnotic drug treatment. Glutethimide and phenobarbital lowered the plasma warfarin concentration and reduced the half‐life of warfarin by nearly 50 per cent. Chloral betaine had less effect but differed significantly from control values. Phenobarbital and glutethimide interfered with the hypoprothrombinemic effect of warfarin; chloral betaine and placebo did not. The findings suggest increased metabolic inactivation of warfarin by induction of liver microsomal enzymes.