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Broad‐spectrum screening of psychotherapeutic drugs: Thiothixene as an antipsychotic and antidepressant
Author(s) -
Overall John E.,
Hollister Leo E.,
Shelton Jack,
Kimbell Isham,
Pennington Veronica
Publication year - 1969
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196910136
Subject(s) - akathisia , anticholinergic , antipsychotic , antidepressant , antipsychotic drug , psychiatry , medicine , sedation , psychology , schizophrenia (object oriented programming) , anesthesia , anxiety
Thiothixene was studied simultaneously in both schizophrenic and depressed patients. Seventy‐two newly admitted schizophrenic patients and 64 depressed patients were treated for 4 weeks with relatively modest doses. As indicated by interview ratings coded on 2 psychiatric rating scales, the drug was highly efficacious in both types of patients, the degree of improvement for each general group of patients being among the highest of our series of evaluations of antipsychotic and antidepressant drugs. When the results of treatment of 5 different schizophrenic Stlbtypes were reviewed, there were no differences between the responses of various types of schizophrenic reactions. The same situation applied to 3 subtypes of depressive reactions. Side effects were chiefly related to weight gain, extrapyramidal syndromes (including akathisia), anticholinergic effects, and sedation.