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Averages and individuals
Author(s) -
Mainland Donald
Publication year - 1968
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196896792
Subject(s) - placebo , clinical trial , medicine , drug , drug trial , placebo group , alternative medicine , pharmacology , pathology
A draft report of a small trial . After the completion of a blindfold two‐group trial, with random assignment of a drug and a placebo, I submitted the draft of areport to the clinical investigators. The numbers in the trial had been small (21 on placebo and 22 on the drug), largely because the drug had been widely used for a number of years and patients who had ever received it were disqualified from the trial. Of the very few previous controlled trials of the drug the largest, very carefully conducted, had revealed, in most of the criteria of assessment, a small average superiority of the drug over the placebo, “significant at the 5 per cent level.” The much sm aller trial, on which I reported, had shown similar average differences, but in none of the clinical criteria were the differences “significant.”