Premium
Effects of hyoscine butylbromide on gut motility
Author(s) -
Guignard J.-P.,
Herxheimer A.,
Greenwood R. M.
Publication year - 1968
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196896745
Subject(s) - medicine , motility , intestinal motility , oral administration , anesthesia , drug administration , biology , genetics
The effect of intravenous and oral hyoscine butylbromide (HBB) on gut motility has been assessed by tape recording bowel sounds in 7 healthy volunteers, with the use of a double‐blind procedure. In 6 of these intravenous administration of 8 mg. of HBB reduced the bowel sounds for 15 to 30 minutes; this was followed by a considerable increase in bowel sounds. Oral administration ot 200 mg. HBB to the same 6 subjects had no effect on the bowel sounds in the succeeding 21,2 to 3 hours. In the seventh subject an impressive increase in bowel sounds occurred promptly after both intravenous and oral HBB. These results show that HBB is poorly absorbed trom the gut and also make it seem very unlikely that the drug has any effect on normal bowel when given by mouth.