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Liver disease in narcotic addicts I. The role of the drug
Author(s) -
Gorodetzky C. W.,
Sapira J. D.,
Jasinski D. R.,
Martin W. R.
Publication year - 1968
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196896720
Subject(s) - morphine , drug , addiction , narcotic , pharmacology , nalorphine , liver function , thymol , medicine , heroin , liver disease , gastroenterology , anesthesia , chemistry , opioid , psychiatry , chromatography , (+) naloxone , receptor , essential oil
Liver function tests were performed on 20 human volunteers before, during, and after the long‐term administration of morphine. No significant differences in the serum glutamic‐oxaloacetic tramaminase, serum glutamic‐pyruvic tramminase, thymol turbidity, or cephalin flocculation were found. It is concluded that the high incidence of abnormal liver function tests observed in morphine and heroin addicts is not due to a direct hepatotoxic effect of the drug.