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Phenylalanine tolerance tests in patients receiving chloramphenicol
Author(s) -
Weksler Marc E.,
Bourke Edmund,
Schreiner George E.
Publication year - 1968
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196895647
Subject(s) - chloramphenicol , phenylalanine , toxicity , haematopoiesis , antibiotics , pharmacology , chemistry , medicine , biology , biochemistry , amino acid , genetics , stem cell
Chloramphenicol has been shown to inhibit the intestinal transport of phenylalanine in animals. Phenylalanine tolerance tests were performed on 22 patients receiving chloramphenicol. Serum phenylalanine levels were depressed in patients with chloramphenicol‐induced hematopoietic toxicity. This alteration in phenylalanine tolerance did not precede the development of hematopoietic toxicity. Impaired intestinal transport of phenylalanine is the most likely explanation for the reduced blood levels. Defective transport of phenylalanine is another manifestation of chloramphenicol toxicity in man.