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Correlation of performance test scores with “tissue concentration” of lysergic acid diethylamide in human subiects
Author(s) -
Wagner John G.,
Aghajanian George K.,
Bing Oscar H. L.
Publication year - 1968
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196895635
Subject(s) - compartment (ship) , lysergic acid diethylamide , body weight , extracellular fluid , plasma concentration , chemistry , extracellular , zoology , medicine , biology , biochemistry , oceanography , geology , receptor , serotonin
Previously published plasma concentrations of LSD‐25, observed following intravenous iniection of 2 mcg. per kilogram of LSD‐25, have been found to be explained by the two‐compartment open model. Performance scores on arithmetic tests were shown to be highly linearly correlated with the concentration in the “tissue” (outer) compartment. The estimated volume of the plasma (inner) compartment was 16.3 per cent of body weight, which is approximately the value reported for extracellular water; the estimated volume of the tissue compartment was 11.5 per cent of body weight. The estimated half‐life for loss of LSD‐25 from the plasma compartment, based on the model, was 103 minutes compared with a half‐life of 180 minutes calculated directly from plasma concentrations.