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Doxycycline monohydrate and hyclate (Vibramycin Monohydrate and Hyclate)
Author(s) -
Pfizer Laboratories
Publication year - 1968
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196893407
Subject(s) - doxycycline , oxytetracycline , pharmacology , chemistry , antibiotics , medicine , chromatography , biochemistry
Vibramycin ( doxycycline) is a new broad‐spectrum antibiotic synthetically derived from methacycline, available as Vibramycin Monohydrate (doxycycline monohydrate) and Vibramycin Hyclate (doxycycline hydrochloride hemiethanolate hemihydrate). The chemical designation of this light‐yellow crystalline powder is α‐6‐deoxy‐5‐oxytetracycline. Vibramycin ( doxycycline) possesses the following useful properties not observed with previously available tetracyclines: its greater absorption from the gastrointestinal tract and its capability for once‐a‐day maintenance dosage.