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The local effect of morphine, nalorphine, and codeine on the diameter of the pupil of the eye
Author(s) -
Nomof Norman,
Elliott Henry W.,
Parker Kenneth D.
Publication year - 1968
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196893358
Subject(s) - nalorphine , miosis , morphine , codeine , pupil , anesthesia , pharmacology , chemistry , medicine , opioid , (+) naloxone , biology , receptor , neuroscience
We have demonstrated that morphine (but not codeine) when applied locally to the coniunctival sac in a solution containing polysorbate produces a small but definite degree of miosis. This is apparently a local effect, since it is significantly greater in the treated than in the untreated eye. Locally applied nalorphine may also produce miosis by direct action; but this drug appears to be absorbed more readily than morphine, and its systemic effect largely masks its local effect. Locally (but not systemically) administered nalorphine, however, antagonizes the miosis produced by local application of morphine.