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The antihypertensive and diuretic effects of amiloride and of its combination with hydrochlorothiazide
Author(s) -
Kampffmeyer Hermann,
Conway James
Publication year - 1968
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196893350
Subject(s) - hydrochlorothiazide , amiloride , diuretic , natriuresis , endocrinology , chemistry , medicine , thiazide , blood pressure , uric acid , potassium , bicarbonate , chloride , triamterene , pharmacology , sodium , organic chemistry
The hypotensive effect as well as changes in serum electrolytes and uric acid of amiloride (AM) and of its combination with hydrochlorothiazide (HC) were studied. In five hypertensive patients over a five‐day period, AM and HC administered together produced more natriuresis than either alone. Potassium, chloride, and bicarbonate concentrations in the serum showed a smaller alteration from normal with the combination than with HC alone. Twelve additional outpatients with moderate hypertension were followed for twelve weeks with the use of randomized Latin squares in double‐blind fashion. A blood pressure‐lowering effect of AM by itself or when added to HC was not seen. AM had no discernible effect on serum glucose, uric acid, or chloride concentrations.