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Toxicity of intraperitoneal bisulfite
Author(s) -
Wilkins James W.,
Greene James A.,
Weller John M.
Publication year - 1968
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196893328
Subject(s) - sodium bisulfite , bisulfite , toxicity , chemistry , intraperitoneal injection , lethal dose , pharmacology , medicine , biochemistry , gene expression , organic chemistry , dna methylation , gene
Studies were carried out in animals to investigate the toxicity of intraperitoneal bisulfite. The LD 50 (dose lethal to 50 per cent of the animals) for a single intraperitoneal injection of NaHSO 3 was calculated in the mouse, rat, rabbit, and dog. Studies indicated that the LD 50 dose was increased by dilution of the bisulfite. When sodium bisulfite was infused at a rate of 80 mg. of NaHSO 3 per kilogram per hour in the portal vein of dogs having bilateral ureteral ligations, bisulfite did not accumulate in the serum. Autoclaving dialysis fluid substantially reduced its bisulfite concentration. These studies suggest that NaHSO 3 in amounts usually added to dialysis solutions is unlikely to cause toxicity in patients undergoing peritoneal dialysis.