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Pharmacological effects in animals and normal human subjects of the diuretic amiloride hydrochloride (MK‐870>
Author(s) -
Baba Walten I.,
Lant Ariel F.,
Smith Anthony J.,
Townshend Mary M.,
Wilson Graham M.
Publication year - 1968
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196893318
Subject(s) - amiloride , triamterene , diuretic , chemistry , endocrinology , medicine , sodium , pharmacology , hydrochloride , hydrochlorothiazide , biochemistry , blood pressure , organic chemistry
Amiloride is a new diuretic drug producing moderate natriuretic effects coupled with prominent potassium retention. Though chemically distinct, this compound has some structural similaritites to triamterene, which it also resembles in its effects in normal human subjects, adrenalectomized rats, and on sodium transport across the isolated frog skin. It has no appreciable effect on the urinary concentrating mechanisms. These actions suggest a primary, direct effect upon the distal renal tubule. A dose‐response relationship in man is obtained with little increase in effect above 40 mg. At lower doses the effects are manifested within the first 10 hours after administration. Doses above 40 mg. prolong these effects to 24 hours.