Premium
Antagonism of the subjective, behavioral, pupillary, and respiratory depressant effects of cyclazocine by naloxone
Author(s) -
Jasinski Donald R.,
Martin William R.,
Sapira Joseph D.
Publication year - 1968
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196892215
Subject(s) - (+) naloxone , depressant , agonistic behaviour , antagonism , narcotic antagonist , pharmacology , opioid antagonist , morphine , antagonist , opioid , naltrexone , anesthesia , psychology , medicine , receptor , psychiatry , aggression
Naloxone is an opioid antagonist with little, it any, agonistic activity. Cyclazocine, on the other hand, in addition to antagoniZing the effects of morphine, produces agonistic effects in man, some of which resemble the effects produced by morphine and some of which do not. The interaction between naloxone and cyclaZOcine Wll8 assessed in 8 subjects. Naloxone antagonized the miotic and respiratory depressant as well as the behaVioral and subjective effects of cyclazocine.