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Effects of angiotensin and norepinephrine infusions on total plasma volume and extracellular fluid space in man
Author(s) -
Werner Mario,
Bock Klaus Dietrich,
Brandenburger Juergen,
Sack Horst
Publication year - 1968
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196892162
Subject(s) - norepinephrine , extracellular fluid , medicine , hematocrit , angiotensin ii , endocrinology , extracellular , intravascular volume status , chemistry , albumin , blood pressure , renin–angiotensin system , biochemistry , dopamine
Pressor doses of angiotensin and norepinephrine were infused into normal subjects for 5 to 6 hours. 125 I‐human serum albumin space, 82 Br space, serum protein concentration, venous hematocrit, blood pressure, and pulse rate were determined at half‐hour intervals before, during, and after the infusions. There were no significant changes in the sizes of 125 I‐human serum albumin space, 82 Br space, and serum protein concentration during and after the administration of the pressor substances. It is concluded that under the conditions of these experiments angiotensin and norepinephrine cause no detectable water movements into or from the intravascular and extracellular space.