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The renal excretion of indomethacin and its inhibition by probenecid
Author(s) -
Skeith Maurice D.,
Simkin Peter A.,
Healey L. A.
Publication year - 1968
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt19689189
Subject(s) - probenecid , renal physiology , excretion , pharmacology , chemistry , secretion , drug , penicillin , medicine , renal function , endocrinology , antibiotics , biochemistry
The renal excretion of labeled indomethacin (indomethacin‐2‐C14) was measured in human volunteers with and without the concurrent administration of probenecid. Acute clearance studies provided evidence of tubular secretion of indomethacin. Less of the drug was excreted when probenecid was given. It is postulated that indomethacin is secreted by the same probenecid‐sensitive tubular mechanism as penicillin and other organic acids.