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Absorption of intestinal antiseptics derived from 8‐hydroxyquinolines
Author(s) -
Berggren Lennart,
Hansson Olle
Publication year - 1968
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt19689167
Subject(s) - excretion , absorption (acoustics) , toxicity , glucuronic acid , chemistry , urinary system , 8 hydroxyquinoline , drug , pharmacology , medicine , biochemistry , organic chemistry , polysaccharide , physics , acoustics
Urinary excretion for 10 hours after a small oral dose of several halogenated 8‐hydroxyquinolines was spectrophotometrically determined in a series of normal human sub;ects. No free forms of drug were found. The determinations were made on the glucuronic acid con;ugates, and the excretions in per cent of the dose were: di‐iodo‐8‐hydroxyquinoline, 4.6 per cent; di‐bromo‐8‐hydroxyquinoline, 10.2 per cent; chloro‐iodo‐8‐hydroxyquinoline, 12.6 per cent; di‐chloro‐methyl‐8‐hydroxyquinoline, 34.9 per cent. Three normal children and two patients (suspected of having 8‐hydroxyquinoline toxicity) who received chloro‐iodo‐8‐hydroxyquinoline had a similar excretion. Human absorption and ocular toxicity are discussed.