Premium
A comparison of hydrolyzed L‐ and synthesized DL‐amino acids for complete parenteral nutrition
Author(s) -
Peaston M. J. T.
Publication year - 1968
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt19689161
Subject(s) - hydrolysis , amino acid , parenteral nutrition , calorie , chemistry , nitrogen , food science , sugar , complete protein , reducing sugar , biochemistry , organic chemistry , medicine
Two comparable groups of patients received high calorie intravenous diets in which the nitrogen was supplied as one of two currently marketed preparations of amino acids. One group received hydrolyzed L‐amino acids and the other a similar nitrogen supply as synthesized DL‐amino acids. Each patient received 2,000 calories per day as soya bean oil fat emulsion in addition to the calories provided by the sugar solutions included with the amino acid preparations. The results confirmed that the hydrolyzed amino acid preparation provides a readily utilizable source of nitrogen for total parenteral nutrition but indicate that the synthesized amino acid preparation containing predominantly DL‐ forms of essential amino acids was not effectively metabolized. It is suggested that the present choice of amino acid preparation for total parenteral nutrition is one containing hydrolyzed L‐amino acids.