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Effect of nicotine and vasopressin on the terminal vascular bed of the heart
Author(s) -
Rakusan Karel,
du Mesnil de Rochemont Wolfgang,
Hanlon Jon,
Braasch Wolfgang,
Tschopp Hans,
Bing Richard J.
Publication year - 1968
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt19689124
Subject(s) - nicotine , vasopressin , medicine , ventricle , skeletal muscle , blood pressure , endocrinology , vasoconstriction , blood flow , heart rate , anesthesia
The effect of nicotine and vasopressin on the capacity of the terminal vascular bed in heart and skeletal muscle of dogs was investigated. In normal heart muscle highest values were obtained in the apex. Nicotine had no significant effect unless the blood pressure increased to very high values. After vasopressin no significant changes were found in heart muscle, but vasoconstriction was present in skeletal muscle. Capillary blood flow determined in heart, lungs, and kidneys of rats increased in all organs after nicotine. In control rats, a slightly but significantly higher capillary blood flow was found in the right ventricle. This difference disappeared in nicotine‐treated animals and became more pronounced after injection of vasopressin.