Bibliographies on diseases of medical progress | Zendy

Harlan Moser Robert | Zendy

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Bibliographies on diseases of medical progress

Author(s) -

Harlan Moser Robert

Publication year - 1968

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1002/cpt196891108

Subject(s) - promethazine , medicine , chlorpromazine , sulfadiazine , dermatology , sensitization , contact dermatitis , dermatitis herpetiformis , patch test , anesthesia , allergy , pharmacology , antibiotics , immunology , disease , microbiology and biotechnology , biology

Over a period of two years the author observed 30 patients in whom contact dermatitis due to promethazine (Phenergan) skin cream was diagnosed. All showed a positive patch test to promethazine cream, and their dennatitis had developed or been aggravated after the use of the cream. In 5 cases the lesions were suggestive of a photodermatitis. Cross‐sensitization was identified by “polyvalent hypersensitivity tests” between paraphenylene diamine in 3 cases, sulfadiazine in 1 case, and chlorpromazine (Thorazine) in 3 cases. The last 3 patients also showed positive skin tests to trimeprazine. Other patients not included in these 30 had positive patch tests to promethazine skin cream but had no evidence of clinical dennatitis.

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