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Time‐series analysis of the effects of barbiturates on the electroencephalograms of psychotic and non psychotic men
Author(s) -
Murphree Henry B.,
Pfeiffer Carl C.,
Goldstein Leonide,
Sugerman A. Arthur,
Jenney Elizabeth H.
Publication year - 1967
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196786830
Subject(s) - pentobarbital , electroencephalography , anesthesia , psychology , barbiturate , differential effects , medicine , psychiatry
Quantitative electroencephalography was used to determine differential neuropharmacological effects of barbiturates in chronic schizophrenic men and nonpsychotic male volunteers. The effects of oral pentobarbital and intravenous thiopental were compared in the two groups. The schizophrenic patients were relatively refractory to the sleep‐inducing effect ot the pentobarbital and showed attenuated responses to this drug in their electroencephalograms in comparison with the nonpsychotic subjects. The patients also showed quantitative electroencephalographic changes consistent with the clinical definition of greater !activation" after the thiopental. Both of these findings suggest that these patients, at least in the experimental setting, tend to be more !alerted" or !overstimulated" than the nonpsychotic subjects.