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Laboratory indices in clofibrate therapy of juvenile‐onset diabetes
Author(s) -
Narduzzi J. V.,
Danowski T. S.,
Weir T. F.,
Alley R. A.,
Vester J. W.,
Moses C.
Publication year - 1967
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196786817
Subject(s) - medicine , endocrinology , clofibrate , transaminase , albumin , globulin , chemistry , creatinine , lactate dehydrogenase , alkaline phosphatase , triglyceride , sorbitol dehydrogenase , cholesterol , biochemistry , enzyme
Clofibrate, 2 Gm. per day, was ingested for 12 to 15 months by 14 adult patients with diabetes of ;uvenile onset. Slight decreases in serum total cholesterol with occasional escape and in NEFA levels tcere recorded in most patients. The total triglycerides and the alpha and beta lipoprotein triglyceride and choleoterol did not change. The serum total proteins, albumin, and creatinine increased, serum globulins decreased, platelets rose, the bleedingtime was slightly prolonged, and the coagulation time shortened at the end of 12 to 15 months of observation, but these indices did not exceed the ranges of normal. Serum glutamic oxalacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) were higher at one month and then mturned to pretherapy values. Lactic acid dehydrogenase (LDH) and malic acid dehydrogenase (MDH) levels decreased gradually, while aldolase and cid phosphatase increased slightly. Serum alkaline phosphatase and creatinephosphokinase(CPK) were unaffected. Bromsulphalein (BSP) retention may have increased very slightly in 3 patients. Peak hyperglycemia following a glucose load was less. Serum protein‐bound iodine (PBl), renal indices, and urinary steroids, pressor materials, and gonadotropins did not change. Many of the above changes suggest slightly altered metabolic eqUilibria during drugtherapy but they may represent changes occurring independently of the drug therapy.