Premium
Studies on beta‐aminopropionitrile in animals
Author(s) -
Keiser Harry R.,
Harris Edward D.,
Sjoerdsma Albert
Publication year - 1967
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196784587
Subject(s) - oxidative deamination , hydroxyproline , monoamine oxidase , urine , deamination , lysyl oxidase , pharmacology , urinary system , chemistry , endocrinology , medicine , biochemistry , enzyme
Single doses of f3‐aminopropionitrile (BAPN) were found to be relatively nontoxic in mice and rats and almost completely excreted in the urine, chiefly as cyanoacetic acid. Importance of oxidative deamination in the drug's metabolism was also indicated by delayed disappearance of the compound in mice pretreated with a monoamine oxidase inhibitor. When BAPN was administered repeatedly to rats, urinary hydroxyproline increased when there were onlyminimal signs of osteolathyrism. These findings provided the basis for prospective clinical trials.