Studies on beta‐aminopropionitrile in animals | Zendy

Keiser Harry R. | Zendy; Harris Edward D. | Zendy; Sjoerdsma Albert | Zendy

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Studies on beta‐aminopropionitrile in animals

Author(s) -

Keiser Harry R.,

Harris Edward D.,

Sjoerdsma Albert

Publication year - 1967

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1002/cpt196784587

Subject(s) - oxidative deamination , hydroxyproline , monoamine oxidase , urine , deamination , lysyl oxidase , pharmacology , urinary system , chemistry , endocrinology , medicine , biochemistry , enzyme

Single doses of f3‐aminopropionitrile (BAPN) were found to be relatively nontoxic in mice and rats and almost completely excreted in the urine, chiefly as cyanoacetic acid. Importance of oxidative deamination in the drug's metabolism was also indicated by delayed disappearance of the compound in mice pretreated with a monoamine oxidase inhibitor. When BAPN was administered repeatedly to rats, urinary hydroxyproline increased when there were onlyminimal signs of osteolathyrism. These findings provided the basis for prospective clinical trials.

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