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The effect of phenyramidol on the metabolism of diphenylhydantoin
Author(s) -
Solomon Harvey M.,
Schrogie John J.
Publication year - 1967
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196784554
Subject(s) - anticonvulsant , metabolism , pharmacology , plasma concentration , anticonvulsant drugs , chemistry , medicine , epilepsy , psychiatry
When phenyramidol was given to subiects taking diphenylhydantoin, the mean biologic alf‐life of diphenylhydantoin increased from 25 hours to 55 hours. In patients taking both drugs simultaneously, elevated plasma concentrations of diphenylhydantoin could account for the increased anticonvulsant effects observed.