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Pain and analgesia evaluated by the intraperitoneal bradykinin‐evoked pain method in man
Author(s) -
Lim R. K. S.,
Miller D. G.,
Guzman F.,
Rodgers D. W.,
Rogers R. W.,
Wang S. K.,
Chao P. Y.,
Shih T. Y.
Publication year - 1967
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196784521
Subject(s) - bradykinin , medicine , anesthesia , pain management , receptor
Synthetic bradykinin WCM in;ected intraperitoneally to produce pain. The optimal individual dose of bradykinin was given every 15 minutes for 120 minutes after analgesic administration. experiments were performed double blind on groups of 16 sub;ects (4 per drug) in a random block design. The pain response WCM recorded by the sub;ect pressing one of four buttons on a pain signal box. Each button registered on a counter at a rate per second corresponding to the button number; the sum of the counts gave the weighted pain score (WPS). The latent period was recorded; it triggered a cutoff timer limiting pain responses to 4 minutes. To evaluate the effect of drugs, the WPS was expressed as a percentage of the individual control WPS and was compared by analysis of variance with the corresponding placebo or other data. Given orally, 650 mg. of aspirin, 20 mg. of dl‐amphetamine, and 100 mg. of meperidine were each analgesic, but half these doses had no such effect. The intraperitoneal in;ection of 20 to 40 mg. of Na‐CMpirin blocks the pain response to subsequent intraperitoneal in;ection of bradykinin, while the same dose given intravenously is ineffective. This suggests that aspirinanalgesia in man may be due to blockade of pain receptors at the periphery.