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The role of dosage form in aspirin‐induced gastrointestinal bleeding
Author(s) -
Leonards Jack R.,
Levy Gerhard
Publication year - 1967
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196783400
Subject(s) - aspirin , placebo , gastrointestinal bleeding , medicine , gastrointestinal tract , bleed , drug , bleeding time , gastroenterology , anesthesia , pharmacology , surgery , platelet , platelet aggregation , alternative medicine , pathology
The relationship of particle size of aspirin to gastrointestinal bleeding produced by this drug was examined in twelve healthy adults who received tablets containing the drug as fine particles, tablets containing relatively coarse particles of aspirin, and placebo tablets. Aspirin in the tablets containing the drug as fine particles dissolved and was absorbed from the gastrointestinal tract much more rapidly than aspirin in the tablets made with coarse particles. There was significantly more gastrointestinal bleeding during aspirin administration than during a control period in which no tablets were administered, but the difference in bleeding produced by the two types of aspirin tablets was not statistically significant. Placebo tablets did not cause gastrointestinal bleeding. Normal blood loss as determined du ring control periods and during placebo administration, respectively, showed a statistically significant correlation. However, subjects who bled rrwst in the control period did not necessarily bleed the most during aspirin administration.