Changes in serum potassium levels occurring in patients treated with triamterene and a triamterene‐hydrochlorothiazide combination | Zendy

Hansen Karl B. | Zendy; Bender A. Douglas | Zendy

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Changes in serum potassium levels occurring in patients treated with triamterene and a triamterene‐hydrochlorothiazide combination

Author(s) -

Hansen Karl B.,

Bender A. Douglas

Publication year - 1967

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1002/cpt196783392

Subject(s) - triamterene , hydrochlorothiazide , hypokalemia , liter , medicine , potassium , hyperkalemia , diuretic , pharmacology , urology , endocrinology , chemistry , blood pressure , organic chemistry

This report summarizes the changes in serum potassium levels in 583 patients treated with triamterene alone, 484 treated with a combination of triamterene and hydrochlorothiazide, and 82 treated with hydrochlorothiazide. The incidence of hypokalemia <3.5 mEq. per liter) in patients treated with a combination of triamterene and hydrochlorothiazide was 6 per cent. Hyperkalemia (>5.4 mEq. per liter) developed in 7.5 per cent of subfects to whom the combination was given, in 12 to 19 per cent of subfects treated with triamterene, and in 4 per cent of patients, especially the severely ill, treated with hydrochlorothiazide.

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