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Latency of cough response as a measure of antitussive agents
Author(s) -
Calesnick Benjamin,
Christensen Jens A.
Publication year - 1967
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196783374
Subject(s) - cough reflex , dextromethorphan , reflex , codeine , anesthesia , latency (audio) , medicine , inhalation , pharmacology , morphine , electrical engineering , engineering
The cough reflex was stimulated in selected healthy male subjects with a single nebulized threshold dose of citric acid. The essential components of the method were deep inhalation by the subjects and the measurement of the required time to elicit the cough reflex. Prolongation of latency was used as a measure of antitussive action. With the use of this parameter, a dose‐response curve was obtained for codeine and dextromethorphan.