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The effect of formulation on phenmetrazine plasma levels in man studied by a sensitive analytic method
Author(s) -
Quinn G. P.,
Cohn M. M.,
Reid M. B.,
Greengard P.,
Weiner M.
Publication year - 1967
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196783369
Subject(s) - plasma concentration , plasma levels , ingestion , plasma glucose , medicine , endocrinology , chemistry , anesthesia , pharmacology , diabetes mellitus
A sensitive method for estimating phenmetrazine concentration in plasma is described. Phenmetrazine is weil absorbed, with average peak plasma levels ab out 2 hours after ingestion and a half‐Ufe in plasma of about 8 hours. A single oral dose of 75 mg. regular tablets results in significant plasma levels for over 12 hours, with highest levels at 2 and 5 hours. A sustained‐release formulation containing the same dose pro duces lower early levels without significantly altering the subsequent blood level pattern.