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Specific therapeutic actions of acetophenazine, perphenazine, and benzquinamide in newly admitted schizophrenic patients
Author(s) -
Hollister Leo E.,
Overall John E.,
Bennett J. L.,
Kimbell Isham,
Shelton Jack
Publication year - 1967
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196782249
Subject(s) - perphenazine , paranoid schizophrenia , antipsychotic , schizophrenia (object oriented programming) , psychiatry , medicine , drug , psychology , psychosis
One hundred newly admitted schizophrenic men were treated with either acetophenazine, perphenazine, or benzquinamide in a controlled study. Each drug produced substantial and essentially equal improvement according to most criteria examined. Classification of patients according to standard nomenclature‐derived prototypes, as paranoid and nonparanoid, revealed no significant differences between drugs, all being somewhat more effective in paranoid patients. Regression analysis revealed a similar trend. The different response to antipsychotic drugs of paranoid as compared with nonparanoid schizophrenic patients provides still further evidence for a difference between these two schizophrenic clinical subtypes.