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A quantitative evaluation of the neurospasmolytic effect of orphenadrine by direct and telemedographed electromyography
Author(s) -
Levine Irving M.,
Jossmann Paul B.,
DeAngelis Vincent
Publication year - 1967
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196781part186
Subject(s) - medicine , electromyography , anesthesia , physical medicine and rehabilitation
Orphenfldrine was evaluated as a neurospasmolytic agent in 14 patients and as an antitremor agent in 2 patients. Response to single 100 mg. doses was measured 1 and 2 hours after medication, and the effect of maintenance therapy with 100 mg. twice a day was measured weekly for 4 weeks. Orphenadrine appeared to be highly effective in the 1 and 2 hour tests but less effective with sustained treatment. In all instances telemedography showed patients had a higher percentage of favorable responses. Orphenadrine was clearly effective in reducing intention tremor in the 2 patients tested with sustained treatment, but less so in the 1 and 2 hour observations.