A quantitative evaluation of the neurospasmolytic effect of orphenadrine by direct and telemedographed electromyography | Zendy

Levine Irving M. | Zendy; Jossmann Paul B. | Zendy; DeAngelis Vincent | Zendy

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A quantitative evaluation of the neurospasmolytic effect of orphenadrine by direct and telemedographed electromyography

Author(s) -

Levine Irving M.,

Jossmann Paul B.,

DeAngelis Vincent

Publication year - 1967

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1002/cpt196781part186

Subject(s) - medicine , electromyography , anesthesia , physical medicine and rehabilitation

Orphenfldrine was evaluated as a neurospasmolytic agent in 14 patients and as an antitremor agent in 2 patients. Response to single 100 mg. doses was measured 1 and 2 hours after medication, and the effect of maintenance therapy with 100 mg. twice a day was measured weekly for 4 weeks. Orphenadrine appeared to be highly effective in the 1 and 2 hour tests but less effective with sustained treatment. In all instances telemedography showed patients had a higher percentage of favorable responses. Orphenadrine was clearly effective in reducing intention tremor in the 2 patients tested with sustained treatment, but less so in the 1 and 2 hour observations.

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