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The anticoagulant response to bishydroxycoumarin: I. The role of individual variation
Author(s) -
Solomon Harvey M.,
Schrogie John J.
Publication year - 1967
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196781part165
Subject(s) - anticoagulant , drug response , drug , variation (astronomy) , anticoagulant therapy , pharmacology , drug metabolism , receptor , medicine , chemistry , physics , astrophysics
Marked variation in anticoagulant response was observed when healthy human volunteers were given 150 mg. of bishydroxycoumarin. This variation in response could not be accounted for by individual differences in the rate of metabolism of bishydroxycoumarin since there was no correlation between the half‐life of the drug and the magnitude of the anticoagulant effect. Differences in the affinity of the receptor site for bishydroxycoumarin may be responsible for the variation in biological response observed among individuals who absorb and metabolize the drug similarly. A clinical example of marked sensitivity to coumarin anticoagulants presumably caused by increased affinity of the receptor site for the drug is presented.