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Advances in control of viral infections by nonspecific measures and by vaccines, with special reference to live mumps and rubella virus vaccines
Author(s) -
Hilleman M. R.
Publication year - 1966
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196676752
Subject(s) - rubella , virology , vaccination , immunology , medicine , immunization , measles , antigen
Vaccines have been most rewarding in their contribution to the safe and effective control of many acute infectious diseases. Additional new vaccines, such as for mumps and rubella, which are reported here for the first time, and for multiple combined forms, will be developed. Application of safe and effective immunologic adjuvants shows promise of decreasing cost and dosage and of improving immunizing performance of killed virus vaccines. Antiviral chemotherapy has shown its first successes and gives special hope to chemoprophylaxis in infections such as those caused by rhino viruses, which are of such antigenic diversity as to be beyond the scope of present hope for effective vaccination. Finally, the door has been opened to possible utilization of natural host resistance mechanisms for combating viral disease by the discovery of interferon, and this approach, in the long run, may offer more than chemotherapy. These approaches, if judiciously used, together provide a real basis for eventual control of the remaining viral diseases of significance to man.