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Hypotensive action of propranolol
Author(s) -
Waal Hendrika J.
Publication year - 1966
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196675588
Subject(s) - propranolol , medicine , cardiology , stroke (engine) , sudden death , heart failure , sudden cardiac death , anesthesia , mechanical engineering , engineering
Coronary heart disease together with sudden cardiac death is now the main cause of death in patients being treated for hypertension at the Wellcome Medical Research Institute, probably because of a reduction in deaths from heart failure and stroke. A hypotensive agent with antiarrhythmic properties might, therefore, be valuable. This work confirms the hypotensive action of the antiarrhythmic agent propranolol in hypertensive patients. In subiects with mild to moderate hypertension, propranolol controlled the hypertension adequately in 30 to 40 per cent. The dose was higher than that necessary for antiarrhythmic effects. The hypotensive effect of propranolol was fully estahlished after one day; no cumulation but rather mild tolerance developed.