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Trial of pipazethate as an antitussive
Author(s) -
Vakil B. J.,
Mehta A. J.,
Prajapat K. D.
Publication year - 1966
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196674515
Subject(s) - placebo , medicine , clinical trial , chronic cough , anesthesia , drug , pharmacology , pathology , alternative medicine , asthma
Pipazethate, thiophenylpyridylamine‐10‐carboxylic acid‐piperidinoethoxyethylester‐HCl, has been reported to have significant antitussive activity in clinical and experimental studies. In a double‐blind study, the drug has been compared with placebo in 70 patients with cough and in 41 healthy subjects in whom cough was artificially induced. The method of Bickerman and Barach was successfully used to induce artificial cough. The present trial suggests that results with pipazethate are no better than with placebo in experimental studies as well as in clinical studies of chronic cough.