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Observations in patients with metastatic malignancy treated with duazomycin A
Author(s) -
Colsky Jacob,
Shnider Bruce I.,
Franzino Arthur,
Perez Jesus
Publication year - 1966
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196673352
Subject(s) - nausea , vomiting , medicine , leukopenia , clearance , stomatitis , diarrhea , malignancy , gastroenterology , anesthesia , chemotherapy , urology
Duazomycin A a glutamine analogue, chemically similar to DON, was studied in 143 patients. An intravenous dose of 3 mg. per kilogram daily for 14 days appeared to be the tolerated dose in humans. Undesirable effects were nausea, vomiting, diarrhea, stomatitis, leukopenia, and thrombopenia. These effects cleared rapidly when the drug was discontinued. Tumor regression was noted in 6 patients but was evanescent and clinically beneficial to only 2.