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Gastric hemorrhage induced by nonnarcotic analgetic agents in dogs
Author(s) -
Davison Clarke,
Hertig David H.,
DeVine Raylene
Publication year - 1966
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196672239
Subject(s) - salicylamide , aspirin , acetaminophen , salicylic acid , bezoar , medicine , anesthesia , pharmacology , chemistry , sucralfate , gastroenterology , biochemistry , psychiatry
The effect of various nonnarcotic analgetic agents in producing gastric hemorrhage has been investigated in Pavlov‐pouch dogs. Of the compounds tested, only aspirin in suspension at pH 3.0 produced extensive bleeding. The same drug in solution, as well as salicylic acid, salicylamide, methylsalicylate, and acetaminophen, produced no significant effect. Intravenous aspirin in high doses failed to cause gastric effects.