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Treatment of pernicious anemia: Historical aspects
Author(s) -
Castle William B.
Publication year - 1966
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196672147
Subject(s) - pernicious anemia , folic acid , megaloblastic anemia , erythropoiesis , medicine , pernicious anaemia , intensive care medicine , anemia , physiology
Highlights in the history of the development of successful and specific treatment for pernicious and other megaloblastic anemias are reviewed. The evolution of knowledge concerning the clinical and physiological basis for their separation into those due to vitamin B 12 and to folic acid deficiencies, respectively, is discussed, and the consequent biochemical abnormalities related to megaloblastic erythropoiesis are briefly presented. The importance of informed collaboration between the medical profession and the pharmaceutical industry for the future initiation, development, and appraisal of new drugs is emphasized.