Premium
The effect of aspirin on pain and hand blood flow responses to intra‐arterial injection of bradykinin in man
Author(s) -
Coffman Jay D.
Publication year - 1966
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt19667126
Subject(s) - bradykinin , aspirin , analgesic , medicine , sodium salicylate , anesthesia , brachial artery , blood flow , plethysmograph , radial artery , vasodilation , pharmacology , artery , blood pressure , receptor
A new method of evoking pain by the intra‐arterial injection of bradykinin (into the brachial artery) was used in the evaluation of the analgesic activity of sodium and calcium acetylsalicylate. At the same time, hand blood flows were measured by venous occlusion plethysmography, and the plasma was analyzed for acetyl, free, and protein‐bound salicylate. The analgesic effect of aspirin appears during the second half of the first hour and continues beyond the second hour after drug administration. Bradykinin increases the hand blood flow and there is an apparent increase in flow after aspirin. No correlation could be found between the plasma salicylate level and the state of analgesia.